There’s a new wave of tweakments sweeping through London’s most luxurious clinics – and looking youthful is no longer about freezing your face. It’s about bringing it back to life.
Dr Brendan Khong, one of the UK’s most in-demand aesthetic doctors, is leading the charge toward regenerative beauty with a treatment that’s being called the future of facial rejuvenation: polynucleotides. It’s all about hydration and glow – not volume or puff. And yes, as arguably the best testament to his work, he even does it to himself.
Dr Brendan Khong is leading the way in regenerative aesthetics
What does the treatment promise?
Forget filler. Polynucleotides go deeper – literally. “Essentially, Nucleofill, which is a brand of polynucleotides, contains DNA fragments that come from certain types of fish – salmon, in the case of Nucleofill,” explains Dr Brendan, speaking to The Luxe Review, “They bind directly to fibroblast cells, triggering the production of collagen and elastin.”
But that’s not all. “They also help stimulate blood vessels, so you get microcirculation, which is great for under the eyes and also for the scalp,” he adds. “It’s great for hair loss too, because it boosts that circulation… and blocks the active molecule derived from testosterone, DHT, which causes hair loss.”
And how about for under the eyes – as an alternative to undereye filler? “They’re great for dark circles and crepey skin,” he confirms. “The only thing I would caution is that the area can be quite swollen after injection.” That’s where we’re trying the treatment ourselves today – and looking at Dr. Khong’s glass-skin results on himself, we’re excited.
How does it work?
Whether you’re here for prevention or repair, polynucleotides are surprisingly gentle. “You can use either a needle or a cannula,” says Dr Brendan. “I tend to use a needle for slightly older patients if they need more surface-level treatment, and a cannula for younger patients – and for myself, actually.”
Yes, you read that right – he even performs the treatment regularly on himself. “Would I trust anyone else?” he laughs, “I do it myself!”
As for what it feels like? “Not really painful,” he promises. “Using a cannula is much less painful than using a needle.” As we are using a cannula, we feel a sharp prick, and then a bit of movement under the eye. It’s more of a pressure than pain, though it does hurt – but using this method, the sensation is over in a minute.
Dr Khong tells us his clients are increasingly switching from filler to polynucleotides for refreshed, youthful skin
What are the results really like?
Discerning aesthetics lovers are increasingly choosing polynucleotides over dermal filler for youthful-looking skin. “I used to do under-eye filler four or five times a week – now I do it maybe once every three months,” Dr Brendan tells us of the shift, “People are choosing polynucleotides instead.”
Even better, this solution doesn’t migrate or puff. Plus, “Filler can sometimes cause a blue tinge… but polynucleotides don’t do that,” he explains. “It just looks natural.”
You’ll see hydration instantly. The area does indeed look more hydrated, juicier, and plumper right away – but the best results show at around two weeks. A course of three sessions, spaced three to four weeks apart, should deliver the best glow-up, Dr. Khong advises, with maintenance top-ups every six to nine months.
Why is Dr. Brendan Khong the expert to trust?
From his sleek West End clinic to his signature precision technique, Dr Brendan has built a reputation for being on the frontier of regenerative skincare.
He’s also his own best advert. “I’m quite ambidextrous, so I can use my left hand on myself – it’s just a bit less steady, so I usually do my right side first, then the left,” he grins. “But it works!”
And if you’re worried about downtime? We found it to be totally minimal. You might like you’ve been crying for a couple of hours – but we found that any marks were gone by the following morning.
The leading regenerative doctor even performs the same treatments on himself, he reveals
What should you know before booking?
This is not a one-and-done filler fix. Polynucleotides are part of the new generation of smart injectables – subtle, cumulative, and cellular-level. It works beautifully under the eyes, and is even making waves in scalp treatments too.
Swelling can happen, so plan accordingly. “If you’re swollen the next day, you can take an antihistamine and sleep slightly elevated,” advises Dr. Khong.
What makes it ideal for luxury lovers?
This is the kind of low-key, high-return tweakment that beauty insiders are whispering about. No tell-tale signs, no overfilling, just rejuvenation from within. And the best part – it’s completely natural.
“It’s a really good preventative treatment… and it’s all natural, so it doesn’t add volume like fillers do,” Dr. Khong tells us, “It just looks natural.”
Who is it best for?
If you’ve tried under-eye filler and weren’t impressed, or were scared off by migration or swelling, this might be your holy grail. It’s perfect for crepey, dull skin, early signs of ageing, or anyone looking for glow over volume. It’s not limited to eyes, either – it’s also ideal for rejuvenating crepey skin on the neck, for example.
Would we get it again?
Absolutely – especially if it makes us look even half as fresh as Dr. Khong himself. Frozen’s out – fresh is in. And thanks to Dr. Khong, we’ve never looked more awake.
Clinic address and contact details
Dr. Brendan Khong Aesthetics Clinic, 120 Pall Mall, St James, SW1Y 5EA +44 02046008685, www.drbrendankhong.com
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The Luxe Review 
There’s a new wave of tweakments sweeping through London’s most luxurious clinics – and looking youthful is no longer about freezing your face. It’s about bringing it back to life.
Dr Brendan Khong, one of the UK’s most in-demand aesthetic doctors, is leading the charge toward regenerative beauty with a treatment that’s being called the future of facial rejuvenation: polynucleotides. It’s all about hydration and glow – not volume or puff. And yes, as arguably the best testament to his work, he even does it to himself.
What does the treatment promise?
Forget filler. Polynucleotides go deeper – literally. “Essentially, Nucleofill, which is a brand of polynucleotides, contains DNA fragments that come from certain types of fish – salmon, in the case of Nucleofill,” explains Dr Brendan, speaking to The Luxe Review, “They bind directly to fibroblast cells, triggering the production of collagen and elastin.”
But that’s not all. “They also help stimulate blood vessels, so you get microcirculation, which is great for under the eyes and also for the scalp,” he adds. “It’s great for hair loss too, because it boosts that circulation… and blocks the active molecule derived from testosterone, DHT, which causes hair loss.”
And how about for under the eyes – as an alternative to undereye filler? “They’re great for dark circles and crepey skin,” he confirms. “The only thing I would caution is that the area can be quite swollen after injection.” That’s where we’re trying the treatment ourselves today – and looking at Dr. Khong’s glass-skin results on himself, we’re excited.
How does it work?
Whether you’re here for prevention or repair, polynucleotides are surprisingly gentle. “You can use either a needle or a cannula,” says Dr Brendan. “I tend to use a needle for slightly older patients if they need more surface-level treatment, and a cannula for younger patients – and for myself, actually.”
Yes, you read that right – he even performs the treatment regularly on himself. “Would I trust anyone else?” he laughs, “I do it myself!”
As for what it feels like? “Not really painful,” he promises. “Using a cannula is much less painful than using a needle.” As we are using a cannula, we feel a sharp prick, and then a bit of movement under the eye. It’s more of a pressure than pain, though it does hurt – but using this method, the sensation is over in a minute.
What are the results really like?
Discerning aesthetics lovers are increasingly choosing polynucleotides over dermal filler for youthful-looking skin. “I used to do under-eye filler four or five times a week – now I do it maybe once every three months,” Dr Brendan tells us of the shift, “People are choosing polynucleotides instead.”
Even better, this solution doesn’t migrate or puff. Plus, “Filler can sometimes cause a blue tinge… but polynucleotides don’t do that,” he explains. “It just looks natural.”
You’ll see hydration instantly. The area does indeed look more hydrated, juicier, and plumper right away – but the best results show at around two weeks. A course of three sessions, spaced three to four weeks apart, should deliver the best glow-up, Dr. Khong advises, with maintenance top-ups every six to nine months.
Why is Dr. Brendan Khong the expert to trust?
From his sleek West End clinic to his signature precision technique, Dr Brendan has built a reputation for being on the frontier of regenerative skincare.
He’s also his own best advert. “I’m quite ambidextrous, so I can use my left hand on myself – it’s just a bit less steady, so I usually do my right side first, then the left,” he grins. “But it works!”
And if you’re worried about downtime? We found it to be totally minimal. You might like you’ve been crying for a couple of hours – but we found that any marks were gone by the following morning.
What should you know before booking?
This is not a one-and-done filler fix. Polynucleotides are part of the new generation of smart injectables – subtle, cumulative, and cellular-level. It works beautifully under the eyes, and is even making waves in scalp treatments too.
Swelling can happen, so plan accordingly. “If you’re swollen the next day, you can take an antihistamine and sleep slightly elevated,” advises Dr. Khong.
What makes it ideal for luxury lovers?
This is the kind of low-key, high-return tweakment that beauty insiders are whispering about. No tell-tale signs, no overfilling, just rejuvenation from within. And the best part – it’s completely natural.
“It’s a really good preventative treatment… and it’s all natural, so it doesn’t add volume like fillers do,” Dr. Khong tells us, “It just looks natural.”
Who is it best for?
If you’ve tried under-eye filler and weren’t impressed, or were scared off by migration or swelling, this might be your holy grail. It’s perfect for crepey, dull skin, early signs of ageing, or anyone looking for glow over volume. It’s not limited to eyes, either – it’s also ideal for rejuvenating crepey skin on the neck, for example.
Would we get it again?
Absolutely – especially if it makes us look even half as fresh as Dr. Khong himself. Frozen’s out – fresh is in. And thanks to Dr. Khong, we’ve never looked more awake.
Clinic address and contact details
Dr. Brendan Khong Aesthetics Clinic, 120 Pall Mall, St James, SW1Y 5EA +44 02046008685, www.drbrendankhong.com
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